Preface

Executive Summary

Chapter 1: The Stem Cell

Chapter 2: The Embryonic Stem Cell

Chapter 3: The Human Embryonic Stem Cell

and The Human Embryonic Germ Cell

Chapter 4: The Adult Stem Cell

Chapter 5: Hematopoietic Stem Cells

Chapter 6: Autoimmune Diseases and the Promise of Stem Cell-Based Therapies

Chapter 7: Stem Cells and Diabetes

Chapter 8: Rebuilding the Nervous System with Stem Cells

Chapter 9: Can Stem Cells Repair a Damaged Heart?

Chapter 10: Assessing Human Stem Cell Safety

Chapter 11: Use of Genetically Modified Stem Cells in

Experimental Gene Therapies

Appendix A: Early Development

Appendix B: Mouse Embryonic Stem Cells

Appendix C: Human Embryonic Stem Cells and Embryonic Germ Cells

Appendix D: Stem Cell Tables

i. Published Reports on Isolation and Differentiation of Mouse Stem Cells

ii. Published Reports on Isolation and Differentiation of Human Fetal Tissue Germ Cells

iii. Published Reports on Isolation and Differentiation of Human Embryonic Stem Cells

iv. Published Reports on Isolation and Differentiation of Human Embryonic Carcinoma Stem Cells

v. Published Reports on Isolation and Differentiation of Human Adult Stem Cells

vi. References

Appendix E: Stem Cell Markers

i. Markers: How Do Researchers Use Them to Identify Stem Cells? . . . . . E-1

ii. Commonly Used Markers to Identify Stem Cells and Characterize Differentiated Cell Types

Appendix F: Glossary and Terms

i. Glossary

ii. Terms

Appendix G: Informational Resources

i. Persons Interviewed

ii. Special Contributions

iii. Acknowledgments

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